Tetracaine Hydrochloride (Tetracaine HCL) Powder CAS 94-24-6
Tetracaine hydrochloride
Synonyms: Tetracaine hydrochloride; 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester hydrochloride
CAS: 136-47-0
EINECS: 205-248-5
Assay: 98.0%-101.0%
Standard: USP32
Packing: 1kg/foil bag; 25kg/cardboard drum
MF: C15H25ClN2O2
MW: 300.82
Character: Tetracaine hydrochloride (136-47-0) is white crystal or crystalline powder, odorless, slightly bitter taste, a sense of numbness of tongue. Tetracaine hydrochloride (136-47-0) soluble in water, dissolved in ethanol, insoluble in ether or benzene.
Usage:Tetracaine hydrochloride is A local anesthetic used topically in opthalmology. Local anesthetic action of Be Proulx Kain strong, 10 times larger than procaine. Toxicity is greater, 10-12 times larger than procaine. Through the mucosa, mainly used for mucosa anesthesia.
Tetracaine Hydrochloride Description:
Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
Tetracaine Hydrochloride Application:
Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.
Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia. In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
Used for mucosal epidermal anesthesia, nerve tissue anesthesia, epidural anesthesia and Subarachnoid space anesthesia.
In the manufacture of pharmaceutical preparation for external use, to relieve the pain of drugs or medication lesions pain.
CTetracaine Hydrochloride OA:
| Test Items |
Specification |
Test Results |
| Appearance |
Fine, white, crystalline, odorless powder |
confirm |
| Identification |
ABC in Pass |
confirm |
| Solubility |
Very soluble in water, soluble in Alcohol;
insoluble in Ether and Benzene |
confirm |
| USP Reference standards |
USP Tetracaine Hydrochloride RS.
USP Endotoxin RS. |
confirm |
| Melting point |
145~150 degree |
146.0~147.5 degree |
| Chromatographic purity |
In Pass |
confirm |
| Related substance |
Not more than the reference solution 0.05% |
confirm |
| Heavy metals |
≤10ppm |
confirm |
| PH |
4.5-6.5 |
5.8 |
| Residue on ignition |
≤0.10% |
0.05% |
| Loss on Drying |
≤ 0.5% |
0.19% |
| Assay |
98.0 -101.0% |
100.1% |
| Conclusion |
Confirms USP 32 |
Rowe Chen
Sales Manager