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Local Anesthesia Powders

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Levobupivacaine (Levobupivacaine Base) Powder CAS 27262-47-1

 

Name: Levobupivacaine Base
Synonyms:1-Butyl-N-(2,6-dimethylphenyl)-piperidine-2-carboxamide;Chirocaine;Levobupivacaine;(2S)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2α-carboxamide;2′,6′-Pipecoloxylidide, 1-butyl-, L-(-)-;1-Butyl-N-(2,6-dimet;;(2S)-1-Butyl-N-(2,6-diMethylphenyl)-2-piperidinecarboxaMide
CAS:27262-47-1
MF:C18H28N2O
MW:288.43
Melting point:136-137°C
Chemical Properties:White Solid
Uses :Local anaesthetic used for epidural and intrathecal anaesthesia.
Packing:1kg/bag

Synonyms: 1-Butyl-N-(2,6-dimethylphenyl)-piperidine-2-carboxamide;Chirocaine;Levobupivacaine;(2S)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2α-carboxamide;2′,6′-Pipecoloxylidide, 1-butyl-, L-(-)-;1-Butyl-N-(2,6-dimet;Levobupivacaine base;(2S)-1-Butyl-N-(2,6-diMethylphenyl)-2-piperidinecarboxaMide

 

Levobupivacaine Description:

 

Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide. It is the S-enantiomer of bupivacaine.
Compared with bupivacaine, levobupivacaine is associated with vasodilation and takes longer. It is about 13% more effective than racemic bupivacaine and has longer duration of block.
Local anesthetics as a Levobupivacaine block production and transmission of nerve impulses, may be by increasing nerve electrical stimulation threshold, slows the transmission of nerve impulses, and lower the rising rate of the action potential. Generally, the progress of anesthesia is associated with the diameter of the affected nerve fibers, the myelin sheath and the conduction velocity. Specifically, the drug binds the cells of the sodium channel and blocks the flow of sodium into the nerve cells to prevent depolarization.

 

Levobupivacaine Applications:

 

Clinical Use

Compared to bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action. It is approximately 13 percent less potent (by molarity) than racemic bupivacaine and has a longer motor block onset time.

 

Indications

Levobupivacaine is indicated for local anaesthesia including infiltration, nerve block, ophthalmic, epidural and intrathecal anaesthesia in adults; and infiltration analgesia in children.

 

Contraindications

Levobupivacaine is contraindicated for IV regional anaesthesia (IVRA).

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