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Local Anesthesia Powders

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Tetracaine (Tetracaine Base) Powder CAS 94-24-6

 

Product Name:Tetracaine
Synonym:Anetain, Amethocaine, Pontocaine,Ametop,Dicaine
CAS:94-24-6
MF:C15H24N2O2
MW:264.36
EINECS:202-316-6
Assay:99%
Quality Standards:EnterpriseStandard/Pharma Grade
Appearance:White powder
Package25kg/Drum

Usage: Tetracaine is a topical local anesthetic for the eyes. Tetracaine works by interfering with entry of sodium ions into nerve cells. This reduces the ability of nerves to generate an impulse and send pain sensations.

 

Tetracaine Description:

 

Tetracaine (INN, also known as tetracaine; trade names Pontocaine.Ametop and Dicaine) are potent topical anesthetics of the ester groups. It is mainly used for ophthalmology and antipruritic agents and has been used for spinal anesthesia. The list of essential medicines in the World Health Organization (WHO) lists the most important drugs required for basic health systems.

 

Tetracaine Application:

 

(1).In biomedical research, tetracaine is used to alter the function of the calcium release pathway (Lannottine receptor), which controls the release of calcium from intracellular stores. Dicaine is an allosteric blocker for channel function. At low concentrations, tetracaine causes initial inhibition of spontaneous calcium release events, whereas at high concentrations, tetracaine is completely released.

(2).Dinkaine is T in Tac, 5 to 12% tetracaine, 5M (countless), half (0.5 ‰) or 0.05% (1 in 2000), 4% or 10% of the salt used for ENT surgery Acid salts, and emergency departments that require rapid surface numbness, especially when children are injured in the eyes, ears or other sensitive parts.

(3).Tetracaine is synthesized from 4-butylaminobenzoic acid. The esterification reaction is carried out by acid catalysis to form ethyl ester. The base-catalyzed transesterification is achieved by boiling ethyl 4-butylaminobenzoic acid with an excess of 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.

 

Tetracaine COA:

 

Test Items Specification Test Results
Appearance Fine, white, crystalline, odorless powder confirm
Identification ABC in Pass confirm
Solubility Very soluble in water, soluble in Alcohol;
insoluble in Ether and Benzene
confirm
USP Reference standards USP Tetracaine Hydrochloride RS.
USP Endotoxin RS.
confirm
Melting point 145~150 degree 146.0~147.5 degree
Chromatographic purity In Pass confirm
Related substance Not more than the reference solution 0.05% confirm
Heavy metals ≤10ppm confirm
PH 4.5-6.5 5.8
Residue on ignition ≤0.10% 0.05%
Loss on Drying ≤ 0.5% 0.19%
Assay 98.0 -101.0% 100.1%
Conclusion Confirms USP 32
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