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Local Anesthesia Powders

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Procaine Hydrochloride (Procaine HCL) Powder CAS 51-05-8

 

Product Name : Procaine Hydrochloride
Synonym: Aminocaine, anadolor, anesthesol, anestil, atoxicocaine, Benzoicacid,4-amino-,2-(diethylamino)ethylester,monohydrochloride, benzoicacid,p-amino-,2-(diethylamino)ethylester,monohydrochloride
Appearance: white crystalline powder
Purity: 99.9%
CAS: 51-05-8
Molecular formula: C13H21ClN2O2
Molecular weight: 72.77
Storage: Shading, confined preservation
Usage: Procaine hydrochloride is a kind of local anesthetics, for local anesthesia, nerve block etc, can block the conduction of nerve fibers with anesthetic effect, strong function, low toxicity, and no addiction, but the skin, mucous membrane penetration force is weak, not suitable for surface anesthesia, clinically used to infiltration, spine and conduction anesthesia.

 

Procaine Hydrochloride Description:

 

Procaine hydrochloride is a topical anesthetic, which can block the nerve fiber conduction temporarilyand has a narcotic effect,strong effect, low toxicity, and non-addictive, but on the skin, mucosal penetration is weak, unsuitable for surface anesthesia, patients are used for infiltration, conduction and spinal anesthesia.

White fine needle crystal or crystalline powder at room temperature, no smell, taste slightly bitter and Ma, soluble in water, soluble in ethanol, slightly soluble in chloroform, almost insoluble in ether. Procaine hydrochloride ester bond structure can be hydrolyzed to produce amino acid and diethylaminoethanol, under certain conditions, the amino acid may be further decarboxylated toxic aniline.

The structure of procaine hydrochloride with aromatic primary amino, easy oxidation discoloration pH, temperature, UV, oxygen and metal ions can accelerate the oxidation discoloration. The aqueous solution was stable in pH3.0~5. So preparation of procaine hydrochloride injection, it generally takes add acid to regulate pH 3.3 to 5.5, and strictly control the sterilization temperature and time. to 100 ℃ steam sterilization 30min circulation is appropriate, and should pay attention to shading, sealed save.

The product structure of aromatic primary amino group in dilute hydrochloric acid can generate diazonium salt with sodium nitrite, coupling reaction occurs when add alkaline β-naphthol, generating azo compounds scarlet.

 

Procaine Hydrochloride Application:

 

Procaine HCl is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. It acts mainly by being a sodium channel blocker.Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.

Procaine HCl is indicated for the production of local or regional analgesia and anesthesia by local infiltration and peripheral nerve block techniques.

 

Procaine Hydrochloride COA:

 

Product name Procaine HCl
Appearance White crystalline powder
Assay (C13H20N2O2·HCl) 99.0% to 101.0% 99.5%
Melting point 153~158ºC 156.5~157.0ºC
Heavy metals ≤20ppm <5ppm
Acidity ≤0.02N NaOH 0.5ml 0.3ml
Chromatographic purity Secondary spots≤0.5%,sum≤1.0% Conforms
Loss on drying ≤1.0% 0.06%
Residue on ignition ≤0.15% 0.03%
Bacterial endotoxins ≤0.6EU/mg <0.6EU/mg
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