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Pramoxine Hydrochloride (Pramoxine HCL) Powder CAS 637-58-1

 

Product name: Pramoxine Hydrochloride,Pramoxine HCL
English Synonyms: Proctofoam; Pramoxine HCL; Praxomine Hydrochloride; Tronothane Hydrochloride; ; pramocaine Hydrochloride;
Synonyms: 4-(3-(p-butoxyphenoxy)propyl)-morpholinhydrochloride ; gamma-morpholinopropyl4-n-butoxyphenyletherhydrochloride ; p-butoxyphenylgamma-morpholinopropyletherhydrochloride ; proctofoam ; Pramoxine HCL ; Praxomine Hydrochloride ; Tronothane Hydrochloride ; 4-[3-(P-BUTOXYPHENOXY)PROPYL]MORPHOLINE Hydrochloride ; 4-n-butoxyphenyl gamma-morpholinopropyl ether hydrochloride ; 4-N-BUTOXYPHENYL G-MORPHOLINOPROPYL ETHER Hydrochloride ; pramocaine Hydrochloride ; 4-[3-(4-butoxyphenoxy)propyl]morpholine Hydrochloride (1:1)
CAS: 637-58-1
EINECS number: 211-293-1
Molecular formula: C17H28ClNO3
Molecular weight: 329.8621
Assay: 99% min
Appearance: White or almost white crystalline powder
Boiling point: 427 ° C at 760 mmHg
Flash Point: Flash Point:
Vapor Pressure: 1.7E-07mmHg at 25 ° C
Standard: USP
Grade: Pharmaceutical Grade

 

Pramoxine Hydrochloride Description:

 

Pramocaine (INN and BAN, also known as pramoxine or pramoxine HCI) is a topical anesthetic discovered at Abbott Laboratories in 1953 and used as an antipruritic. Chemically, it is p-n butoxyphenyl gammamorpholinopropyl ether hydrochloride. During research and development,pramoxine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially good topical local anesthetic agent.
Pharmacologic study revealed it to be potent and of low acute and subacute toxicity, well tolerated by most mucous membranes and of a low sensitizing index in man. Like other local anesthetics,paramoxine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranes is thus inhibited, leading to numbness.

 

Pramoxine Hydrochloride Application:

 

The popular itch creams Gold Bond and some forms of Calamine Lotion use pramocaine hydrochloride to numb sensitive skin, as does the pain relief variant of Neosporin and some formulations of Sarna. The hydrochloride salt form of pramocaine is water-soluble.
Topical anesthetics are used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, and minor cuts and scratches. Pramocaine and dibucaine are also common ingredients in over the counter hemorrhoid preparations

 

Pramoxine Hydrochloride COA:

 

Items of analysis Specification Results
Description White or off- white powder Off- white powder
Solubility Freely soluble in water and in alcohol ,soluble in chloroform,very slightly soluble in ether complies
PH About 4.5 4.45
IdentifIcation IR,HPLC,IdentifIcation Complies
Melting point 172.6ºC~173.5ºC 170ºC~174ºC
Loss on drying ≤1.0% 0.59%
Residue on ignition ≤0.1% 0.03%
Ethyl acetate ≤0.089% Not detected
Ethanol ≤0.5% 0.06%
Petroleum ether ≤0.5% 0.02%
Triethylamine ≤0.5% Not detected
Isopropanol ≤0.5% Not detected
Assay 98.0%-102.0% 99.56%
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