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GW-501516 (Cardarine/GSK-516) Powder (317318-70-0)

 

Product Name GW-501516 / Cardarine
Alias 2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2-methylphenoxy)acetic acid
Synonyms 2-(4-((2-(4-(TRIFLUOROMETHYL)PHENYL)-5-METHYLTHIAZOL-4-YL)METHYLTHIO)-2-METHYLPHENOXY)ACETIC ACID;2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic Acid;Methyl-methyl-trifluoromethylphenyl -thiazolyl-methylsulfanyl-phenoxy-acetic Acid;2-(4-((2-(4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic acid;GW 1516;2-(2-methyl-4-((5-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-4-yl)methylthio)phenoxy)acetic acid;GW501516, Free Acid;GSK-516
CAS 317318-70-0
MF C21H18F3NO3S2
MW 453.5
Product Categories Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;kl;Inhibitor;Antineoplastic;SARMs(Selective androgen receptor modulator)
Appearance White powder
Purity 99.12%
Usage 1, It had been investigated as a potential treatment for obesity, diabetes, dyslipidemia and cardiovascular disease.
2, GW501516 could be used by athletes and bodybuilders as an ergogenic performance enhancing drug.

 

GW-501516 (Cardarine/GSK-516) Description:

 

GW501516 (GW1516 or GSK-516) is a drug that acts as a PPARd modulator. GW 501516 activates AMP-activated protein kinase and stimulates glucose uptake in skeletal muscle tissue, and GW 501516 has been demonstrated to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome, most likely by stimulating fatty acid oxidation. It has been proposed as a potential treatment for obesity and related conditions, especially when used in conjunction with a synergistic compound AICAR, as the combination has been shown to significantly increase exercise endurance in animal studies. GW-50156 regulates fat burning through a number of widespread mechanisms; it increases glucose uptake in skeletal muscle tissue and increases muscle gene expression, especially genes involved in preferential lipid utilization. This shift changes the body’s metabolism to favor burning fat for energy instead of carbohydrates or muscle protein, potentially allowing clinical application for obese patients to lose fat effectively without experiencing muscle catabolism or the effects and satiety issues associated with low blood sugar. GW-501516 also increases muscle mass, which improved glucose tolerance and reduced fat mass accumulation even in mice fed a very high fat diet, suggesting that GW-501516 may have a protective effect against obesity.

 

GW-501516 (Cardarine/GSK-516) Application:

 

An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream. A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARd agonist. GW-501516 is a unique medication officially classified as a PPAR receptor agonist (PPAR-RA). Research for this medication began in 1992 in a conjoined effort between GlaxoSmithKline (GSK) and Ligand Pharmaceuticals. Research into this product was set forth in an effort to provide treatment for various cardiovascular diseases, as well as diabetes, obesity and other conditions. It was soon discovered that the PPAR-RA was highly effective at enhancing endurance. It had been investigated as a potential treatment for obesity, diabetes, dyslipidemia and cardiovascular disease. GW501516 could be used by athletes as an ergogenic performance enhancing drug.

GW 501516 (Cardarine) is one of the most versatile performance enhancers one will ever come across.
Whether you are looking to drastically increase endurance, melt fat, cut or recomp, GW will truly shine. In this article, I am going to touch on the many ways and reason to incorporate GW into every cycle that you run. There is a place for GW in every cycle, regardless of the desired goal. It can only add extra benefits that will further enhance the chances of accomplishing goals and maximizing gains.

There are two main uses with GW-501516. The first and most common use is that of increased endurance. GW has been banned for professional athletes due to the unfair advantage it provides to endurance athletes. Anyone want a drastic increase in endurance will find that GW truly shines in this aspect. It takes effect very quickly and the results can be staggering. A common dose of 10 mg day will provide a significant increase in endurance.

The second common usage with GW is that of fat loss. Many users turn to GW as it has shown to melt off fat while still being non-catabolic. You will find that you can still hold on to some muscle as you are losing fat. It helps when you are running it in conjunction with SARMS Ostarine and S4, to hold on to as much muscle as possible.

 

GW-501516 (Cardarine/GSK-516) Function:

 

Based on its positive attributes, GW-501516 may be one of the single best products an athlete could buy. However, although not an anabolic steroid, numerous sporting bodies have already banned it and it will show up in sports doping tests. But when it comes to the benefits, endurance and enhancing nutrient efficiency are two benefits that are hard to beat. It’s hard to beat this into the head of many athletes, recovery, endurance and food itself are the three most important factors associated with making gains or improving performance, and GW-501516 does just that.

Although the benefits of GW-501516 are undeniable, we are still left with the glaring possibility of use-induced cancer. Regardless of how much muscle you carry or how low your body fat is, cancer is going to ruin the physique you’ve built, not to mention your life. The odds of cancer, from looking at some of the studies that were done they do appear to be somewhat flawed, while others scream warning.

It is truly hard to say what would happen if you were to try this drug, but there does appear to be a legitimate risk, and enough of one to cause a very large pharmaceutical giant to completely give up on what could have been a highly profitable drug had the cancer scare not existed.GW501516 (also known as GW-501,516, GW1516, GSK-516 and Endurobol)is a PPAR receptor.

It activates the same pathways activated through exercise, including PPAR and AMP-activated protein kinase. It had been nvestigated as a potential treatment for obesity, diabetes, dyslipidemia and cardiovascular disease. GW501516 has a synergistic effect when combined with AICAR: the combination has been shown to significantly increase exercise endurance in animal studies more than either compound.

An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream. A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARδ agonist.

Exhibits selectivity for PPARδ compared to PPARα and PPARγ. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells.

 

Recommendations & Dosing Guidelines for GW-501516 (Cardarine/GSK-516)

 

10-20 mg per day is a sufficient dose. It is recommended to start at 10mg per day to take advantage of the host’s sensitivity to the new chemical. 10 mg a day is aimed for endurance, and the higher the dosage the greater the fat loss benefits are going to be

Lab mice should be given dosages 45 minutes- 1 hour before exercise.

GW501516 has been tested for a 2 year study and has found no decreases or stagnation in effects. Most individuals run cycles for 12-14 weeks at a time with a 4-6 week break. This is normally to coincide with a SARM cycle, but there is no evidence showing that GW 501516 needs to be off-cycled after such a short amount of time. GW501516 was created for LONG TERM usage, so there is no reason why it shouldn’t be used that way.

Half life is between 16-24 hours and should be take at 10mg once a day or 10mg once every 10-12 hours if taken at a higher dose.

No PCT is needed, GW is recommended in combination with PCT if highly toxic anabolics have been used.

Highly recommended to use with a ketogenic diet.

Can be used in conjunction with anabolics and stimulants of any kind without adverse reactions.

 

How GW-501516 (Cardarine/GSK-516) Works

 

GW stimulates glucose uptake and skeletal muscle tissue. It burns fat by stimulating fatty acid oxidation. It’s suggested as a potential treatment for obesity because of it’s ability to rapidly melt fat. Also, Cardarine is said to increase HDL by an average of 79% (good cholesterol) and decrease LDL (bad cholesterol) in current Phase II trials. GW 501516 is a PPARδ agonist. These help increase your HDL levels from an enhanced expression of the cholesterol transporter ABCA1.

 

The Side Effects of GW-501516 (Cardarine/GSK-516):

 

Not to say that there are none, but in the last 20 years no side effects have been seen by anyone studying the drug.

GW501516 has not only been tested in healthy subjects, but also those with simulated “real life” habits (such as drinking alcohol, stimulant narcotics, and the use of tobacco products). It is uncertain if there are long term ramifications, but no research has been published stating otherwise.

This is what makes Cardarine so incredibly popular and usable over long periods of time. In certain studies, there have even been signs showing the reversal of diabetes, obesity, Dyslipidemia and many other diseases.

 

GW-501516 (Cardarine/GSK-516) & Liver Damage:

 

In contrast to popular belief, GW501516 doesn’t promote damage of liver cells. The chemical has actually been known to promote healthy liver function and faster healing properties to the skin and muscle tissue. In essence, you will not heal rapidly like Wolverine from the X Men movies, but you will shorten the your recovery time from scratches, blisters, and injured muscles by a significant amount.

 

GW-501516 (Cardarine/GSK-516) & Cancer:

 

There has been many forum comments expressing the concerns of GW501516 and it’s relationship to cancer and tumor development. The hypothesis for this controversy stems from GW’s ability to improve angiogenesis in the body at an extremely high rate and the rate of cancer growth in the colons of lab mice. Angiogenesis refers to the bodies ability to increase blood supply to feed the cells throughout the body.

This is a common occurrence among endurance athletes and children going through adolescence. Scientist had speculation that if there were tumor cells active in the body, that they would be especially susceptible to angiogenesis and cause the tumor to grow at a much faster rate. Since 2004 many experiments have been done to prove this hypothesis, but so far, all of them have been largely unsuccessful.

A study published in 2004 by the American Association of Cancer Research stated that PPAR agonists have

“…shown to have no effect on the proliferation of colorectal cancer cells” and “…under normal culture conditions, PPAR activation has no effect on cell growth”.

Keep in mind that this study was done in rats given amounts of 400 mg a day and was abused and ran for hundreds of weeks to top it all off. Time and time again this study has been refuted and shown to be deeply flawed and inaccurate.

In a 2008 experiment done on human breast cancer and colon cancer cells, not only did the PPAR agonist GW 501516 prove to be safe for use, it has proven to inhibit cancer cell growth. The National Institute of Health has confirmed without a reasonable doubt that GW 501516 inhibits a multitude of cancers in human cells.

Over a decade of research studies on human PPAR beta (the primary target of GW) has only proven a decrease in cancer cells with extended use (up to two years). The confusion for these previous allegations of cancer growth were from results published in 1996 and have long since been abandoned due to new clinical research. The chemical compound has been dosed in human PPAR for a number of years and has only provided positive results on cancer treatments, liver function, and metabolic efficiency.

In all of the human studies done so far, there were no noticeable side effects at all while running GW.

 

Stacking GW-501516 (Cardarine/GSK-516) :

 

Stacking Cardarine means running it in combination with other compounds. What makes Cardarine stand out is it can be used with almost anything (cutting, bulking or recomping).

Bulking – clean up your gains and make that bulk cleaner while maintaining size.

Cutting – totally optimal when it comes to weight loss while holding on to muscle mass.

Recomping – perfect for building lean muscle and losing fat

The most common way to use Cardarine is in a triple stack involving LGD 4033 and MK 2866. You’ll have all the gains, endurance, fat loss and size gains by taking all three.

 

GW-501516 (Cardarine/GSK-516) Half Life:

 

The half life of cardarine is 20-24 hours. This means that once a day dose is totally fine. Some athletes like to use all the 20 mg an hour before their workout session, and others will split the dose in half in the AM and PM.

It is best to squirt the liquid into your mouth, swallow, and then chase down with some juice or water.

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