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Ace-031 (ACVR2B) 1mg

 

Product Name :ACE 031
Certification:SGS/ISO9001/Kosher
Place of Origin:China
Minimum Order Quantity:10 vials
Price:Negotiation
Payment Terms:Western Union,Money Gram ,Bitcoin or T/T
Supply Ability:5000 Vial per month
Delivery Time:After receipt of your payment
Packaging Details:Original Kits or as requirements
Product Name:ACE 031,Polypeptide Hormones,Peptide Hormones,Bodybuilding Supplements

Unit:1mg/vial ,10vial/kit

Synonyms:ACE-031, ActRIIb-hFc, ACVR2B, activin receptor type IIB and human immunoglobulin Fc region construct, myostatin inhibitor.

Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Specificity:The amino acid sequence of the recombinant human ActRIIb-hFc is 100% homologous to the amino acid sequence of the human ActRIIb receptor and immunoglobulin Fc region proteins.

Solubility:Add 1 ml of sterile diluent and let the lyophilized pellet dissolve completely.
Stability:Store lyophilized protein at -20 °C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 °C for a limited period of time. The lyophilized protein remains stable until the expiry date when stored at -20 °C.

Ace-031, also known as ACVR2B, is a soluble form of activin type IIB receptor, which is an inhibitor of myostatin and other naturally occurring proteins that limit muscle growth. This compound was genetically developed to bind to myostatin before it can attach to its receptor and halt muscle growth. The two Biopharma companies that worked on this compound are Acceleron and Shire.

Development of ACE-031 is fully discussed in Diverting an Unwanted Protein, in the April 2011 issue of Quest, MDA’s quarterly research and health magazine.

Companies hope to resume ACE-031 testing after safety issues fully explored

Acceleron and Shire are completing studies of ACE-031 in rats and monkeys and will analyze the human and animal data to gain an understanding of the observed adverse events. The companies say they hope to resume testing ACE-031 in humans after these analyses have been obtained and reviewed by the U.S. Food and Drug Administration (FDA) and Health Canada.

 

Ace-031 (ACVR2B) COA:

 

Appearance White to off white powder Consistent
Purity(HPLC) ≥98% 99%
Water <6.0% 5.43%
Acetic Acid 3.0-8.0% 6.45%
Trifluoroacetic Acid <0.25% 0.08%
Peptide ≥80% 88.45%
MS Consistent Consistent

 

Ace-031 (ACVR2B) Description:

 

ACE-031 is a soluble fusion protein that has been shown to increase muscle mass and strength in the study. ACE-031 is being studied as a metabolic disease, children with kidney tumors, cardiovascular abnormalities, age-related muscle loss and cancer treatment-related muscle loss and neuromuscular disease treatment.

ACE-031 is a biotherapeutic agent based on activin receptor type IIB (ActRIIB). The molecule binds to ActRIIB receptors to inhibit signaling and increases muscle mass and intensity. ACE-031 is a recombinant fusion protein synthesized by fusion of standard antibodies and partial ActRIIB receptors. Recombinant fusion proteins eliminate myogenic inhibin and other biomolecules that limit muscle strength or growth.

ACE-031 is for research purposes only. ACE-031 should not be used for human consumption, diagnosis, treatment procedures, agriculture and veterinary purposes.

 

Ace-031 (ACVR2B) Application:

 

Some bodybuilders use ACE-031 to promote muscle growth and improve lean muscle. ACE-031 No serious adverse events. Most common adverse events are mild and tolerant. The polypeptide contains 368 amino acid molecules that form a very large polypeptide complex. Muscle growth is regulated by the production of amino acids, and the TGFβ protein superfamily is primarily a regulator, and as mentioned above, the switch mechanism is essential for muscle production. When the ActRIIB receptor interacts with GDF-8, it emits an opening signal that promotes muscle growth.

 

Acceleron and Shire issued the following statement on April 21:

 

“In an effort to keep the Duchenne muscular dystrophy community informed, Acceleron and Shire wish to provide an update about the status of the ACE-031 clinical program.

“During the course of clinical trials in healthy adults and in DMD boys, some participants experienced minor nosebleeds, gum bleeding, and/or small dilated blood vessels within the skin. These events all resolved fully upon discontinuation of treatment.

“By themselves, the minor bleeding events and dilated blood vessels were not considered to be a serious safety concern for study subjects.

“However, based on review of these safety data with the FDA and Health Canada, Acceleron has terminated the A031-03 DMD study and has suspended enrollment and dosing in the follow-on extension study A031-06.

“Acceleron and Shire remain committed to the global DMD clinical program and the development of ACE-031. To that end, it is our intention to start new studies of ACE-031 in DMD with appropriate safety monitoring following discussions with regulatory agencies.

“In the coming months, we will provide updates to the DMD community as appropriate.”

 

What is ACE-031?

 

ACE-031 is an investigational (experimental) drug that is designed to increase muscle size and strength by blocking proteins that slow down muscle growth. ACE-031 is a protein drug that is administered by subcutaneous injection.

 

How does ACE-031 work on muscle?

 

Muscle growth is regulated by proteins in the body that serve as “on” or “off” switches for muscle production. ACE-031 acts by reducing the “off” signal that stops muscle production, thus muscles may become larger and stronger.

 

Why is ACE-031 being studied in Duchenne Muscular Dystrophy (DMD)?

 

ACE-031 may promote muscle growth and improve muscle quality, which may compensate for loss of muscle strength and function due to disease-related muscle damage that occurs in DMD. Because it acts on muscle, ACE-031 has the potential to treat all DMD patients, regardless of their type of dystrophin mutation.

 

What does ACE-031 do in animal models of DMD?

 

In animal studies, including healthy animals and animal models of DMD, ACE-031 has been shown to increase the size of muscles and decrease the amount of abnormal scarring in muscle. ACE-031 has also been shown to increase the protein utrophin, which may partially make up for the lack of dystrophin, which causes DMD. The significance of this effect on utrophin is not yet known.

 

Half life:

 

The half life of Ace-031 is 10-15 days.

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