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Anti-Estrogen Powders

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    • Specifications

     

    Raloxifene Hydrochloride (Raloxifene HCL) Powder (82640-04-8)

     

    Alias: Raloxifene HCl; KEOXIFENE; AKOS 92138
    CAS: 82640-04-8
    Purity: 99%
    MF: C28H28ClNO4S
    MW: 510.04
    Appearance: Light yellow powder
    Related Substances: Pharmaceutical Grade
    Storage: Shading, confined preservation
    Lead time: 1-2 days upon receipt of payment
    Delivery Term: Products below 200Kg by air; Over 200Kg by ship
    Delivery Time: Average 6 days by air; 15 days by ship
    Usage: It is used in the prevention of osteoporosis in postmenopausal women.

     

    Raloxifene Hydrochloride Description:

     

    Evista (Raloxifene Hydrochloride) is an estrogen agonist/antagonist, referred to as a selective estrogen receptor modulator (SERM) and belongs to the benzothiophene class of compounds. The biological actions of Raloxifene are largely mediated through binding to estrogen receptors. This binding results in activation of estrogenic pathways in some tissues (Agonism) and and the blockade of estrogenic pathways in other tissues (Antagonism).

     

    Raloxifene Hydrochloride Application:

     

    May prevent or treat corticosteroid-induced bone loss. American College of Rheumatology states that raloxifene can be offered to selected postmenopausal corticosteroid-treated women who refuse hormone replacement therapy or other antiresorptive agents (e. G., bisphosphonates, calcitonin) or in whom such therapies are contraindicated.

    Reduction in the incidence of invasive breast cancer in postmenopausal women with osteoporosis.

    Reduction in the incidence of invasive breast cancer inpostmenopausal women at high risk for developing the disease. Effect comparable to that of tamoxifen in reducing the risk of invasive breast cancer (STAR trial). No effect on the risk of lobular carcinoma in situ or ductal carcinoma in situ (STAR trial). Effect on breast cancer incidence in women with BRCA1 or BRCA2 genetic mutations not established.

    Not indicated for the treatment of breast cancer or to reduce the risk of recurrence of breast cancer. 1 Not indicated for reduction in the risk of noninvasive breast cancer.

    Side effect: Raloxifene may infrequently cause serious blood clots to form in the legs, lungs, or eyes. Other reactions experienced include leg swelling/pain, trouble breathing, chest pain, vision changes. Raloxifene is a teratogenic drug, i. e., can cause developmental abnormalities such as birth defects.

     

    Raloxifene Hydrochloride COA:

     

    ITEMS SPECIFICATION RESULT
    Appearance White &off-white powder Conform
    Solubility Soluble in 10% sodium hydroxide solution. Slightly Soluble in methanol. Insoluble in water Conform
    Identifications Infrared Absorption Conform
    Chloride Conform
    Tests Loss on drying ≤0.5% 0.4%
    Residue on ignition ≤0.1% 0.06%
    Heavy metals ≤10ppm Conform
    Related substances ≤0.20 % 0.10%
    Any unspecified individual impurity 2 ≤0.10% Max. 0.08%
    Total impurities ≤0.50% 0.40%
    Assay Raloxifene HCl ≥98.0% 99.0%

     

     

    Raloxifene Hydrochloride Use and Dose:

     

    Evista is specifically approved for the treatment and prevention of osteoporosis in postmenopausal women, the reduction in risk of invasive breast cancer in postmenopausal women with osteoporosis and the reduction in risk of invasive breast cancer in postmenopausal women at high risk of invasive breast cancer. Evista is supplied as a 60 mg tablet designed for oral administration. The recommended initial dose of the drug is one 60 mg tablet daily, which may be administered any time of day without regard to meals.

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