Toremifene Citrate (Fareston) Powder (89778-27-8)
CAS: 89778-27-8
Assay:99%
Appearance: White or almost white powder
Molecular Formula: C26H28ClNO·C6H8O7
Molecular Weight: 598.09
Melting Point: 158-164 ºC
Boiling Point: 535.1 ºC at 760 mmHg
Refractive index: 1,416-1,418
Toremifene Citrate (Fareston) Description:
Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body. Licensed in the United States under the brand name Fareston, toremifene citrate is FDA-approved for use in advanced (metastatic) breast cancer. It is also being evaluated for prevention of prostate cancer under the brand name Acapodene.
It has already been covered that Toremifene is a SERM, and serves to block Estrogen at various receptor sites in certain tissues within the body (breast tissue in particular). As a layman explanation, Toremifene pretends to be a ‘fake’ Estrogen that occupies Estrogen receptors within breast tissue. With these receptors occupied by Toremifene, real Estrogen cannot perform their jobs there.
Toremifene Citrate (Fareston) COA:
| TEST ITEMS |
SPECIFICATION |
RESULTS |
| Description |
White or Almost White Crystalline Powder |
White Powder |
| Identification |
Positive |
Positive |
| Assay |
97.00~103.00% |
99.38% |
| Loss On Drying |
0.5%max |
0.25% |
| Melting Point |
95~99ºC |
96.0~98.0ºC |
| Specific Rotation |
+48°~+51° |
+49.0° |
| Organic Volatile Impurities |
meets the requirments. |
Conforms |
| Residual Solvents |
meets the requirments. |
Conforms |
| Conclusion |
The specification conform with USP32 standard |
Toremifene Citrate (Fareston) Applications:
Toremifene Citrate improved lipid profiles, particularly as an enhancer of high density lipoprotein cholesterol. it improved low density lipoprotein cholesterol levels.Both fareston and tamoxifen selective estrogen receptor modulators and equivalent treatments for metastatic breast cancer.
In treating idiopathic oligozoospermia, tamoxifen and fareston are roughly equally effective but raloxifene is not.The antiestrogenic effects of SERMs at the hypothalamic level result in a statistically significant increase of gonadotropin levels, which is more marked for tamoxifen and fareston compared with raloxifene
Toremifene Citrate (Fareston) Usage:
Originally developed to fight breast cancer, bodybuilders have used Fareston to successfully fight gynocomastia caused when testosterone converts to estrogen in the body and men grow breasts. This substance can be used for little else and other similar compounds, such as Nolvadex or Clomid, are much more effective in post-cycle-therapy.
Rowe Chen
Sales Manager