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High Quality Cetilistat(Cetislim) Powder For Weight Loss



Cetilistat Quick Details



CAS 282526-98-1

CAS 282526-98-1 Brand: Renyoung
Min order: 10grams MW: 401.58
Usage Cetilistat is used to treat obesity.
Product Categories: Pharmaceutical Raw Materials,Active Pharmaceutical Ingredients,Bulk Drugs,Fine Chemicals.
Standard purity:>99%
Appearance White Crystal powder
Shelf life 2 years
Storage Cetilistat should be stored in a well-closed container at low temperature, keep away from moisture, heat and light.


Is Cetilistat powder effective?

The clinical efficacy and safety of Cetilistat powder has been demonstrated in a series of Phase II trials. A Phase IIb clinical trial in 612 clinically obese diabetic patients showed that over a 12-week treatment period, Cetilistat powder 80mg and 120mg promoted significant weight loss compared with placebo (3.85kg and 4.32kg versus 2.86kg respectively), thus meeting the trial’s primary endpoint.

  • It does not act on the central nervous system;
  • Fighting obesity;
  • Does not take away the appetite;
  • It helps reduce weight and improve body composition;
  • Does not cause mood changes such as anxiety and nervousness;
  • Its use is released by ANVISA.



Cetilistat powder Uses

Cetilistat powder(Cetislim) is an anti-obesitiy medicine which helps promote weight loss by inhibiting the enzyme called pancreatic lipase. This enzyme is secreted by the pancreas and normally acts inside the intestine where it helps to breakdown fat and triglycerides. By preventing the activity of this enzyme, the hydrolysis of triglycerides (types of bad fats) is partially prevented. This results in a significantly reduced amount of free fatty acids and fats being absorbed into body, especially after fatty foods have been consumed.

Any remaining undigested fat is unable to be absorbed and is instead eliminated from the body as faeces. Treatment can help to lessen visceral fat and bodyweight, however patients should note that the use of medication to treat obesity needs to be accompanied by dieting, exercise and other lifestyle changes. This will help to minimize the risk of developing chronic diseases associated with being overweight, such as type 2 diabetes.



What are the Dosage and Cycles For Cetilistat powder?

Cetilistat powder dosage is provided as 60mg strength capsules for administration orally. The medicine is taken with meals to ensure that it can work while the food is being digested, so that the absorption of fat from the diet can be effectively reduced. Your physician will advise you on how much medicine to take with each dose, as well as the required daily dosage. It is very important that you adhere to these instructions. Do not take more than your physician tells you to take.



What are the side effects of Cetilistat powder?

Patients undergoing treatment for obesity with Cetislim (Cetilistat powder) powder could suffer from side effects. You must inform your physician if this happens. Some examples are given here:

  • Fat in stool
  • Abdominal cramp
  • Flatus with discharge
  • Oily spotting
  • Bowel incontinence
  • Flatulence
  • Abdominal Pain
  • Diarrhoea
  • Soft stools
  • Nasal congestion
  • Frequent defecation
  • Pain in the stomach

Although mild reactions are generally considered to be more common, serious adverse events may also occur. Consult your physician immediately should this occur.



What is the solubility of Cetilistat powder in neat solvents?

The solubility of Cetilistat powder in neat solvents of acetone, isopropanol, acetonitrile and water were determined experimentally by using the isothermal dissolution equilibrium method within the temperature range from (278.15 to 323.15) K under atmospheric pressure of 101.1 kPa. At the fixed temperature, the mole fraction solubility of Cetilistat raw powder was greater in acetone than in the other three neat solvents. They ranked as acetone > isopropanol > acetonitrile > water. The obtained solubilities were correlated with Apelblat equation. The largest value of relative average deviation was 0.86 × 10− 2, and of root-mean-square deviation, 15.55 × 10− 4. Furthermore, the preferential solvation parameters (δx1,3) of Cetilistat powder in co-solvent mixtures of acetone (1) + water (2), isopropanol (1) + water (2) and acetonitrile (1) + water (2) were derived from their thermodynamic properties by means of the inverse Kirkwood–Buff integrals method. The values of δx1,3 varied non-linearly with the co-solvent (1) proportion in all the aqueous mixtures. The preferential solvation parameter was negative in water-rich mixtures but positive in intermediate composition and co-solvent-rich mixtures. In the latter case, it was conjecturable that Cetilistat powder was acting as a Lewis acid with co-solvent molecules. The co-solvent action might be related to the breaking of the ordered structure of water around the polar moieties of Cetilistat raw powder which increased the solvation of this drug. The solubility data and thermodynamic study expanded the physicochemical information about Cetilistat powder in binary solvent mixtures, which was required in the pharmaceutical and chemical industries to save time and money in the optimization of the solubilization and/or crystallization process designs.



Cetilistat powder really can lose weight?

Several researches claim that Cetilistat powder tablet it works to inhibit the absorption of fat. Its effect is analyzed mainly by the amount of fat present in the feces of people who underwent treatment with the drug.

In a study published in the British Journal of Clinical Pharmacology, volunteers who underwent treatment with Cetilistat raw powder showed a considerable increase of fat in their feces compared to the group and did not take the drug. The same study concluded that treatment with Cetilistat powder is effective to prevent the absorption of intestinal fat in healthy subjects who received a controlled diet.

Clinical trials conducted by the Japanese laboratory Takeda, maker of Cetilistat raw powder showed that people who underwent treatment with the drug for 12 weeks lost more weight than the control group that received only a placebo.

The study of 612 obese patients, the group receiving Cetilistat powder at a dose of 120 mg kg 4:32 lost on average, while the group that received 80 mg Cetilistat raw powder eliminated 3.85 kg. The control group, which received only a placebo lost 2.86 kg in 12 weeks.

That is, there was a weight loss of at least 25% more in groups using the Cetilistat powder than the group maintained the same diet but did not receive the medicine.



How to use Cetilistat powder to treat obesity?

The growing prevalence of obesity has stimulated the search for drugs to treat this condition. Various therapeutic strategies have been explored, including:

  • Serotonin and noradrenaline reuptake inhibitors (anorectic agents)
  • Lipase inhibitors
  • b 3-adrenoreceptor agonists
  • Leptin agonists
  • Melanocortin-3 agonists
  • Endocannabinoid receptor antagonists

Cetilistat powder is a lipase inhibitor, with a similar mode of action to Roche’s anti-obesity medication orlistat (Xenical®) which received regulatory approval in 1997. These drugs act in the gastrointestinal tract to inhibit lipases, enzymes involved in the breakdown of dietary fats. By inhibiting the breakdown and subsequent absorption of fats from the gut, lipase inhibitors reduce fat intake and calories, thus aiding weight loss.


What special precautions should be followed while taking Cetilistat powder?

  • Do not stop taking the medication abruptly unless instructed by the doctor. Stopping the medication suddenly may cause the illness to return.
  • Avoid consumption of alcohol as it may alter the absorption of
  • Keep the medication out of reach of children.
  • You are advised not to take Cetilistat powder if

it has passed the expiry date of the medicine printed on the pack.
the foil or packaging is torn or shows signs of tampering or there is discolouration.


How to convent Cetilistat powder into oral capsules 60mg?

Cetilistat powder Receipes Formula:

02# capsule filling tools 100mg/capsule Cetilistat powder 150g

Cetilistat powder dose: 60mg/dose

100mg/capsule-Cetilistat raw powder 60mg/dose=40mg/dose corn starch

Cetilistat powder 60mg/dose:40mg/dose corn starch=3:2

150g Cetilistat raw powder: 150mg corn starch powder=3:2

150g + 100g =250g 250g=250,000mg

250,000mg ÷ 100mg/capsule=2500capsules(Cetilistat powder)



What is difference for Orlistat and Cetilistat powder?


Cetilistat powder, a novel gastrointestinal lipase inhibitor, appears to be as effective in the management of obesity and its comorbidities as another lipase inhibitor, orlistat, while demonstrating better tolerability, according to two phase 2 randomised, double-blind, placebo-controlled, 12-week studies.

“Lipase inhibition has proven efficacy in obese patients and in obese patients with diabetes,” said Tom, dean, faculty of health, University of East Anglia, Norwich, United Kingdom, who presented the two studies on behalf of the Cetilistat raw powder European Study Group here at the 15th European Congress on Obesity (ECO).

The first study investigated the use of Cetilistat powder in 372 obese patients with a body mass index (BMI) > 30, in centres throughout Europe. All patients received intensive dietetic counselling throughout the study and consumed a prescribed diet that was calculated to be approximately 500 kcals below their weight-maintaining diet. In addition, patients were given 60, 120, or 240 mg of Cetilistat raw powder, or placebo, at mealtimes, three times daily.

Significant weight loss was achieved in all treatment groups at 12 weeks, with a 3.5-kg reduction in weight achieved with 120 mg Cetilistat powder three times daily versus placebo (P <.05).

“Cetilistat powder was effective in inducing weight loss in 12 weeks of study,” Dr. Tom said in a presentation on April 23rd. “In addition, there were significant reductions in waist circumference.”

In the second study presented by Dr. Tom, the researchers enrolled 612 obese subjects with type 2 diabetes, who were taking metformin. Many of the patients were also on statins, and about a third were also taking antihypertensive medication.

As in the previous study, patients received a hypocaloric diet and one of three different doses of Cetilistat raw powder (40, 80, or 120 mg), or placebo. In addition, a fourth study group was randomised to 120 mg of orlistat 3 times daily.

Dr. Tom said that significant weight reductions were achieved in all treatment groups, with approximately 35% of subjects on the highest Cetilistat powder dose achieving a weight loss of about 5% of their initial body weight or more. In addition, there were statistically significant reductions in glycosilated haemoglobin (HbA1c) over 12 weeks.

Although the efficacy data were comparable between Cetilistat rawpowder and orlistat, considerable differences emerged between these two drugs regarding their tolerability profiles, according to Dr. Tom.

Overall, patients treated with orlistat had nearly twice as many serious adverse events — primarily gastrointestinal — leading to treatment discontinuation than in the Cetilistat powder group. The rate of severe adverse events leading to discontinuation was comparable between the placebo group and those receiving Cetilistat powder.

On the basis of these results, Dr. Tom concluded that Cetilistat raw powder has a favourable tolerability profile, and it is safe and efficacious in the management of obesity and its comorbidities.

Funding for these studies was provided by Dewael Biotechnology Powder, the manufacturer of Cetilistat powder.


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