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Tadalafil Cialis Application:
Although sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis) all work by inhibiting PDE5, tadalafil’s pharmacologic distinction is its longer half-life (17.50 hours) – compared to sildenafil (4.0–5.0 hours) and vardenafil (4.0–5.0 hours) – resulting in longer duration of action, and so partly responsible for “The Weekend Pill” sobriquet. Furthermore, the longer half-life is the basis for current investigation of tadalafil’s daily therapeutic use in relieving pulmonary arterial hypertension. Sildenafil is approved in several world regions as a thrice-daily therapy for pulmonary arterial hypertension.
Tadalafil Citrate Quick Details :
| product name | Tadalafil Citrate |
| Alias | Cialis, Tadalafil |
| CAS | 171596-29-5 |
| Molecular formula | C22H19N3O4 |
| Molecular weight | 389.40 |
| Assay | 99.5% |
| Grade | Pharmaceutical Grade |
| Storage | Shading, confined preservation |
| Appearance | white powder, odorless, tasteless, insoluble in water and alcohol |
| Usage | leads to smooth muscle relaxation, blood flows into the penile tissue, produce an erection, such as sexual stimulation. |
Cialis is an effective, reversible, selective inhibitor of phosphodiesterase type 5 (PDE 5) specific to cyclic guanosine monophosphate (cGMP). When sexual stimulation causes local release of nitric oxide, inhibition of PDE 5 by Cialis leads to increase of cGMP levels in the cavernous body of penis. It results in relaxation of arterial smooth muscles and blood flow to the tissues of the penis that causes erections. Cialis has no effect when sexual stimulation is absent. Cialis improves erection and lets achieve a successful sexual intercourse. The drug acts during 36 hours. If sexual arousal is present the effect appears even after 16 minutes after the medication was taken.
Do not take CIALIS if you:
After taking a single tablet, some of the active ingredient of CIALIS remains in your body for more than 2 days. The active ingredient can remain longer if you have problems with your kidneys or liver, or you are taking certain other medications.
Stop sexual activity and get medical help right away if you get symptoms such as chest pain, dizziness, or nausea during sex. Sexual activity can put an extra strain on your heart, especially if it is already weak from a heart attack or heart disease.
CIALIS is not right for everyone. Only your healthcare provider and you can decide if CIALIS is right for you. Ask your healthcare provider if your heart is healthy enough for you to have sexual activity. Do not take CIALIS if your healthcare provider has told you not to have sexual activity because of your health problems. Before taking CIALIS, tell your healthcare provider about all your medical problems, particularly if you have or ever had:
Tell your healthcare provider about all the medicines you take, especially:
CIALIS is also marketed as ADCIRCA for the treatment of pulmonary arterial hypertension. Do not take both CIALIS and ADCIRCA. Do not take sildenafil citrate (Revatio) with CIALIS.
CIALIS should not be taken more than one time each day. If you miss a dose, you may take it when you remember but do not take more than one dose per day. Take CIALIS exactly as your healthcare provider prescribes it.
Do not use other ED medicines or ED treatments.
Do not drink too much alcohol (for example, 5 glasses of wine or 5 shots of whiskey). Drinking too much alcohol can increase your chances of getting a headache or getting dizzy, increasing your heart rate, or lowering your blood pressure.
The most common side effects with CIALIS are: headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. These side effects usually go away after a few hours. Men who get back pain and muscle aches usually get it 12 to 24 hours after taking CIALIS. Back pain and muscle aches usually go away within 2 days. Call your healthcare provider if you get any side effect that bothers you or one that does not go away.
Uncommon but serious side effects include: