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Pharmaceutical Chemicals

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Synephrine Powder (94-07-5)

 

Product Name: Synephrine
Alias: oxedrine;SYNEPHERINE;SYNEPHRINE;4-hydroxy-alpha-(methylaminomethyl) enzyl alcohol
CAS: 94-07-5
Molecular Formula: C9H13NO2
Molecular Weight: 167.21
EINECS No.: 202-300-9
Grade: medical grade
Appearance: white powder
Chemical properties: Light yellow to off-white fine powder
Product Resource: Extracted from the dried immature fruit of Citrus aurantium L.
Category: plant extracts
Field: health food
The extension of products: synephrine slimming capsule
Use: lose weight, get excited

 

Synephrine Description:

 

Synephrine, or, more specifically, p-synephrine, is an alkaloid, occurring naturally in some plants and animals, and also in approved drugs products as its m-substituted analog known as neo-synephrine.

p-Synephrine and m-synephrine are known for their longer acting adrenergic effects compared to norepinephrine. This substance is present at very low concentrations in common foodstuffs such as orange juice and other orange (Citrus species) products, both of the “sweet” and “bitter” variety. The preparations used in Traditional Chinese Medicine (TCM), also known as Zhi Shi, are the immature and dried whole oranges from Citrus aurantium (Fructus Aurantii Immaturus).

Extracts of the same material or purified synephrine are also marketed in the US, sometimes in combination with caffeine, as a weight-loss-promoting dietary supplement for oral consumption. While the traditional preparations have been in use for millennia as a component of TCM-formulas, synephrine itself is not an approved OTC drug.

As a pharmaceutical, m-synephrine is still used as a sympathomimetic (i.e. for its hypertensive and vasoconstrictor properties), mostly by injection for the treatment of emergencies such as shock, and rarely orally for the treatment of bronchial problems associated with asthma and hay-fever.

It is important to distinguish between studies concerning synephrine as a single chemical entity (and even here it should be borne in mind that synephrine can exist in the form of either of two stereoisomers, d- and l-synephrine, which are chemically and pharmacologically distinct), and synephrine which is mixed with other drugs and/or botanical extracts in a “Supplement”, as well as synephrine which is present as only one chemical component in a naturally-occurring mixture of phytochemicals such as the rind or fruit of a bitter orange.

Mixtures containing synephrine as only one of their chemical components (regardless of whether these are of synthetic or natural origin) should not be assumed to produce exactly the same biological effects as synephrine alone.

 

Synephrine Application:

 

In application of traditional Chinese medical science, it is used to dispel bloating and a lump in the abdomen and phlegm, and to cureedema, constipation, gastroptosis, prolapse of uterus and rectocele. Anti- tumour, prevent osteoporosis, reduce cholesterin and protect heart.Nerve protection and prevent diseases of degeneration of nerve. Relieve menopausal symptoms of women, improve bone metabolism and protect cardiovascular system, etc.

The drug synephrine is a common medicine that is used for weight loss. Although it is used by a large number of people, its effectiveness has yet to be conclusively proven. Synephrine comes from a type of citrus fruit and is sometimes known as bitter orange. Usually the drug is taken orally although it can also be injected in certain situations. Some of the claims suggest synephrine can increase a person’s energy, allow for greater weight loss and increase body temperature.

Synephrine has become more popular recent years due to another popular weight loss drug being banned. The drug ephedrine is no longer legally sold in many countries due to the health risks that are associated with taking it.

Synephrine is lime fruits of the main active ingredient, which can effectively prevent excess energy (heat accumulation), by the wind qi, warm the stomach stimulates the appetite and speeds up metabolism.

It is also a mild fragrance expectorant agent, a neurological tranquilizers and laxative treatment of constipation. Users can expect variable effects include consumption of excess calories, reduce appetite and increase satiety, these are likely to lead to weight loss.

 

Synephrine Main Function:

1) With the function of antibacterial and anti-fungi, it can resist various bactirier, such as staphylococcus aureus, Escherichia coli, shigella dysenteriae, typhoid bacillus;

2) With the function of lowering blood cholesterol, reducing thrombosis, improving micro-circulation and nutrient supply, it can effectively prevent cerebrovascular diseases.

3) It has the function of spasmolysis and cholagogue.

4) It has the function of anti-inflammatory and sedative;

5) It has the function of anti-cancer, aldose reductase inhibitory effect of the eye.

Synephrine Dosage:

A recommended dosage is 10-20mg, taken thrice a day.

Acute dosages of 50mg are also frequently used, although not thrice a day.

 

Synephrine COA :

 

Identification Positive reaction Verified
Appearance powder Complies
Color White Complies
Odor Characteristic Complies
Loss On Drying <0.5% Complies
Mesh Size 80mesh Complies
Heavy Metals <10ppm Complies
Total Plate Count <1000cfu/g Complies
Yeast & Mold <100cfu/g Complies
Salmonella Negative Negative
E.Coli Negative Negative
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