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Pharmaceutical Chemicals

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  • Specifications


Rimonabant Hydrochloride (Rimonabant HCL) Powder (158681-13-1)


Appearance:White powder


Rimonabant Hydrochloride Descriptions:


(1) Rimonabant hydrochloride (SR-141716A) is a potent and selective CB1 inverse agonist/antagonist with a Ki of 1.6 nM, minimal affinity for CB2, and and some GPR55 agonist activity. Rimonabant was developed as an anti-obesity drug because of its appetite suppressant activity, but was taken off the market because of side effects of depression and anxiety.
(2) Under development by Sanofi-Aventis, Acomplia (rimonabant) is a selective CB1 endocannabinoid receptor antagonist indicated for the treatment of obesity.
(3) It works by blocking endogenous binding to neuronal CB1 receptors. Activation of these receptors by endoegenous , such as anadamide, increases appetite. It is the most advanced endocannabinoid receptor antagonist in clinical development and offers a novel therapeutic approach to appetite control and weight reduction.


Rimonabant Applications:


(1). Rimonabant hydrochloride has a favorable safety profile and is generally well tolerated. Rimonabant is proving to be a very promising approach for managing two major and preventable risk factors for cardiovascular disease. This review summarizes the available evidence on the clinical efficacy and safety of rimonabant as a potential therapy for obesity and smoking cessation.
(2). Rimonabant hydrochloride also has potential as a treatment for smoking cessation because the endocannabinoid system is involved in the body’s response to tobacco dependence.


Rimonabant Hydrochloride COA:


Appearance White &off-white powder Conform
Solubility Soluble in 10% sodium hydroxide solution. Slightly Soluble in methanol. Insoluble in water Conform
Identifications Infrared Absorption Conform
Chloride Conform
Tests Loss on drying ≤0.5% 0.4%
Residue on ignition ≤0.1% 0.06%
Heavy metals ≤10ppm Conform
Related substances ≤0.20 % 0.10%
Any unspecified individual impurity 2 ≤0.10% Max. 0.08%
Total impurities ≤0.50% 0.40%
Assay Raloxifene HCl ≥98.0% 99.0%
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