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Minoxidil Sulfate Powder (83701-22-8)

 

Product Name:Minoxidil Sulphate
Synonyms:Minoxidilsulfateester;6-(1-Piperidinyl)-2,4-Pyrimidinediamine-3-Oxide Sulfate;Minoxidil Sulfate;u-58838;Minoxidil Sufate Ethylated;1,6-Dihydro-6-Imino-4-(1-Piperidinyl)-1-(Sulfooxy)-2-Pyrimidinamine;Minoxidil o-Sulfate
CAS:83701-22-8
MF:C9H15N5O4S
MW:289.31
Melting point:175-180°C
Assay:99%
Chemical Properties:White Crystalline Solid
Usage:A selective ATP-sensitive potassium channel opener. It is the active metabolite of minoxidil and is a potent (IC50=0.14μM) vascular smooth muscle relaxant.
Packing:25kg/drum

 

Minoxidil Sulphate Description:

 

Minoxidil was the first drug approved by the FDA for the treatment of androgenetic alopecia (hair loss). Before that, minoxidil had been used as vasodilator drug prescribed as oral tablet to treat high blood pressure, with side effects that included hair growth and reversal of male baldness. In the 1980s, UpJohn Corporation came out with a topical solution of 2% minoxidil, called Rogaine, for the specific treatment of androgenetic alopecia. Since the 1990s, numerous generic forms of minoxidil have become available to treat hair loss while the oral form is still used to treat high blood pressure.

The popularity hair loss treatment is due to the general preference in the overall population for the cosmetic appearance of a full head of hair. Minoxidil is used to stimulate hair growth in areas of the scalp that have stopped growing hair. As of early 2001, the exact mechanism of action of minoxidil is not known.

 

Minoxidil Sulphate Application:

 

Minoxidil tablets contain Minoxidil, an antihypertensive peripheral vasodilator. Minoxidil occurs as a white to off-white, odorless, crystalline solid that is soluble in water to the extent of approximately 2 mg/mL, is readily soluble in propylene glycol or ethanol, and is almost insoluble in acetone, chloroform or ethyl acetate. The chemical name for Minoxidil is 2,4-pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxide. The structural formula is represented at right.

Minoxidil was the first drug approved by the FDA for the treatment of androgenetic alopecia (hair loss). Before that, minoxidil had been used as vasodilator drug prescribed as oral tablet to treat high blood pressure, with side effects that included hair growth and reversal of male baldness. In the 1980s, UpJohn Corporation came out with a topical solution of 2% minoxidil, called Rogaine, for the specific treatment of androgenetic alopecia. Since the 1990s, numerous generic forms of minoxidil have become available to treat hair loss while the oral form is still used to treat high blood pressure.

The popularity hair loss treatment is due to the general preference in the overall population for the cosmetic appearance of a full head of hair. Minoxidil is used to stimulate hair growth in areas of the scalp that have stopped growing hair. As of early 2001, the exact mechanism of action of minoxidil is not known

 

Minoxidil Sulphate COA:

 

Test items Specifications Results
Appearance White or almost white crystalline White or almost white crystalline
Identification Positive Positive
Residue on ignition ≤0.5% 0.05%
Heavy metals ≤20ppm 5ppm
As ≤1ppm ≤1ppm
Pb ≤1ppm ≤1ppm
Loss on drying ≤0.5% 0.15%
Organic volatile impurities Accord with USP30 Accord with USP30
Total Impurities ≤1.5% Conform
purity (HPLC) 98% 99.47%
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