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Local Anesthesia Powders

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Lidocaine (Lidocaine Base) Powder CAS 137-58-6

 

Product name:Lidocaine
Alias:Xylocaine,lignocaine,L-Caine; Leostesin; 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide; Esracaine; 2-diethylamino-2′,6′-acetoxylidide;
CAS Registry Number:137-58-6
Assay:99%
Appearance:White crystalline powder
Packing:25kg/drum
EINECS:205-302-8
Molecular Formula:C14H22N2O
Molecular weight:234.34
Usage:Topically used to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic, or as a local anesthetic for minor surgery.

 

Lidocaine Description:

 

Lidocaine, xylocaine, or lignocaine is a common local anesthetic and class-1b antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning, and pain from skin inflammations, injected as a dental anesthetic, or as a local anesthetic for minor surgery.It is on the World Health Organization’s List of Essential Medicines, a list of the most important medications needed in a basic healthcare system.

Lidocaine is the most important class-1b antiarrhythmic drug; it is used intravenously for the treatment of ventricular arrhythmias (for acute myocardial infarction, digoxin poisoning, cardioversion, or cardiac catheterization) if amiodarone is not available or contraindicated. Lidocaine should be given for this indication after defibrillation, CPR, and vasopressors have been initiated. A routine prophylactic administration is no longer recommended for acute cardiac infarction; the overall benefit of this measure is not convincing.

 

Lidocaine Applications:

 

The efficacy profile of lidocaine as a local anesthetic is characterized by a rapid onset of action and intermediate duration of efficacy. Therefore, lidocaine is suitable for infiltration, block, and surface anesthesia. Longer-acting substances such as bupivacaine are sometimes given preference for subdural and epidural anesthesias; lidocaine, though, has the advantage of a rapid onset of action.

Epinephrine (adrenaline) vasoconstricts arteries, reducing bleeding and also delays the resorption of lidocaine, almost doubling the duration of anaesthesia. For surface anesthesia, several available formulations can be used e.g. for endoscopies, before intubations, etc. Buffering the pH of lidocaine makes local freezing less painful.[2] Lidocaine drops can be used on the eyes for short ophthalmic procedures.

Relative insensitivity to lidocaine is genetic. In hypokalemic sensory overstimulation, relative insensitivity to lidocaine has been described in people who also have attention deficit hyperactivity disorder.In dental anesthesia, a relative insensitivity to lidocaine can occur for anatomical reasons due to unexpected positions of nerves. Some people with Ehlers-Danlos syndrome are insensitive to lidocaine.

Lidocaine, along with ethanol, ammonia, and acetic acid, has also been proven to be effective in treating jellyfish stings, both numbing the affected area and preventing further nematocyst discharge

 

Lidocaine COA:

 

Item Standard Result
Characteristics A white or almost white crystalline powder Conform
Identification Should meet related requirements Conform
Appearance of solution Should meet related requirements Passed
PH 3.5-5.5 4.5
Specific optical rotation +135°~+150° +143°
Boiling point 350.8°C at 760 mmHg Conform
Flash point 166°C Conform
Lincomycin B 5.0% max 2.9%
Heavy metals 5ppm max Conform
Residue on ignition 0.5% max 0.1%
Water 3.1-4.6% 4.3%
Bacterial endotoxins smaller than 0.5IU/mg smaller than0.5IU/mg
Assay Not less than 89.5% and not more than 102.0% of lincomycin (C18H35ClN2O6S)) 99%
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