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  • Specifications

 

GDF-8 1mg

 

Product Name:GDF-8
Unit Size :1 mg/vial
Unit Quantity :1 Vial
Synonyms :Myostatin
Appearance :White Powder
Purity :99%
Source :Chemical Synthesis
Storage :Lyophilized GDF-8 is stable at room temperature for 90 days,however it should be stored in a freezer below -8C for any extended period of time. After reconstituting MGF should be refrigerated at temperatures not to exceed 36 F.

Please note:This product is for research use only.

 

GDF-8 Abstract:

 

Myostatin (GDF-8) is a member of the transforming growth factor-beta (TGF-beta) superfamily that is highly expressed in skeletal muscle, and myostatin loss-of-function leads to doubling of skeletal muscle mass. Myostatin-deficient mice have been used as a model for studying muscle-bone interactions, and here we review the skeletal phenotype associated with altered myostatin signaling. It is now known that myostatin is a key regulator of mesenchymal stem cell proliferation and differentiation, and mice lacking the myostatin gene show decreased body fat and a generalized increase in bone density and strength. The increase in bone density is observed in most anatomical regions, including the limbs, spine, and jaw, and myostatin inhibitors have been observed to significantly increase bone formation. Myostatin is also expressed in the early phases of fracture healing, and myostatin deficiency leads to increased fracture callus size and strength. Together, these data suggest that myostatin has direct effects on the proliferation and differentiation of osteoprogenitor cells, and that myostatin antagonists and inhibitors are likely to enhance both muscle mass and bone strength.

 

GDF-8 Specifications:

 

Biological activity:The ED50 as determined by the inhibition of the proliferation of MPC-11 cells is < 20ng/ml, corresponding to a Specific Activity of 50,000units/mg.

 

GDF-8 Applications:

 

Western blot
Functional Studies
SDS-PAGE

Purity:> 95 % SDS-PAGE.
This product is purified by proprietary chromatographic techniques. Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Form:Lyophilised
Additional notes:For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).

 

Preparation and Storage:

 

Stability and Storage

 

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Preservative: None.
Additives: None.
This product is an active protein and may elicit a biological response in vivo, handle with caution.

 

GDF-8 Reconstitution:

 

Reconstitute in sterile 20mM HCl at 0.1 mg/ml, which can then be further diluted to other aqueous solutions.

 

General Info:

 

Alternative names

GDF 8
GDF-8
GDF8
GDF8_HUMAN
Growth differentiation factor 8
Growth/differentiation factor 8
MSLHP
MSTN
Myostatin
OTTHUMP00000163498

 

GDF-8 Function:

 

Acts specifically as a negative regulator of skeletal muscle growth.

Sequence similarities

Belongs to the TGF-beta family.

Cellular localization

Secreted.

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