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Dutasteride (Avodart) Powder (164656-23-9)

 

Dutasteride (Avodart)
English Synonyms: (5alpha,17beta)-n-{2,5-bis(trifluoromethyl)phenyl}-3-oxo-4-azaandrost-l-ene-17-carboxamide;DUTASTERIDE;GG-745, GI-198745,;5α,17β)-N-[2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4- Aza -androst-1-ene-17-carboxamide;Duagen;(5a,17)-N-[2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4-azaandrost-1-ene-17-carboxamide;Avodart;GI 198745
CAS NO.: 164656-23-9
Assay: 99%
Molecular Formula:C27H30F6N2O2
Molecular Weight:528.53
Packing:1kg/tin/foil bag
Standard: Enterprise/USP
Appearance: White or almost white crystalline powder
Usage: Prostate enlargement, male pattern hair loss, seborrheic alopecia, hereditary hair loss

 

Dutasteride (Avodart) Description:

 

Dutasteride (trademark name Avodart) is a dual 5-α reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT). Used for benign prostatic hyperplasia; however, it increases the risk of erectile dysfunction and decreased sexual desire.

Dutasteride useful for the symptoms of benign prostatic hyperplasia (BPH); colloquially known as an “enlarged prostate”. In those who are being regularly screened 5-alpha-reductase inhibitor (finasteride and dutasteride) reduce the overall risk of being diagnosed with prostate cancer however there is insufficient data to determine if they have an effect on the risk of death and may increase the chance of more serious cases.

 

Dutasteride (Avodart) Application:

 

This class of medications increases rates of erectile dysfunction (with between 5% and 9% developing problems after starting their use). This is linked to lower quality of life and can cause stress in relationships. There is also an association with lowered sexual desire. It has been reported that these adverse sexual side effects may persist even after discontinuation of the drug. The FDA has added a warning to dutasteride about an increased risk of high-grade prostate cancer.

While the potential for positive, negative or neutral changes to the potential risk of developing prostate cancer with dutasteride has not been established, evidence has suggested it may temporarily reduce the growth and prevalence of benign prostate tumors, but could also mask the early detection of prostate cancer.

The primary area for concern is for patients who may develop prostate cancer whilst taking dutasteride for benign prostatic hyperplasia, which in turn could delay diagnosis and early treatment of the prostate cancer, thereby potentially increasing the risk of these patients developing high-grade prostate cancer.

 

Dutasteride (Avodart) COA:

 

Test Items Specification Test Results
Description White or almost white powder Complies
Identification Meet the requirements Complies
Loss on drying ≤0.5% 0.2%
Melting range 246℃~252℃ 246℃~248℃
Heavy metals ≤20ppm Complies
Residue on ignition ≤0.1% Complies
Related substances Biggest Impurities≤0.5% 0.36%
Total Impurity≤1.0% 0.7%
Assay 97.0%~103.0% 99.5%
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