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Dapoxetine Powder (119356-77-3)

 

Dapoxetine Powder
CAS No.: 119356-77-3
Synonyms: DAPOXETIN; DAPOXETINE
Molecular Weight: 341.88
Molecular Formula: C21H23NO HCL
Assay: 99%min
Appearance: White crystalline powder

 

Dapoxetine Description:

 

Dapoxetine, marketed as Priligy and Westoxetin, among and other brands, is the first compound developed specially for the treatment of premature ejaculation (PE) in men 18-64 years old.Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin’s action at the post synaptic cleft, and as a consequence promoting ejaculatory delay.As a member of the selective serotonin reuptake inhibitor (SSRI) family, dapoxetine was initially created as an antidepressant. However, unlike other SSRIs, dapoxetine is absorbed and eliminated rapidly in the body. Its fast acting property makes it suitable for the treatment of PE but not as an antidepressant.

 

Dapoxetine Applications:

 

Treat male premature ejaculation and erectile dysfunction.Dapoxetine, marketed as (among and other brands) is the first compound developed specially for the treatment of premature ejaculation (PE) for men at th age of 18-64 years old. Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin’s action at the post synaptic cleft, so as to delay ejaculation.. As a member of selective serotonin reuptake inhibitor (SSRI) family, Dapoxetine was initially created as an antidepressant. However, unlike other SSRIs, Dapoxetine is absorbed and eliminated rapidly in the body. Its fast response makes it suitable for the treatment of PE but not as an antidepressant.

Due to the lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as Fluoxetine, Paroxetine, Sertraline, Fluvoxamine, and Citalopram have been used as clinical drugs to treat PE. Waldinger’s meta analysis shows that the use of these conventional antidepressants increases IELT from two to nine times above base line in comparison of three to eight times when Dapoxetine is used. However, these SSRIs must be taken daily in order to achieve meaningful efficacy, and the long half-life increases the risk of the drug accumulation and as a consequence an increased adverse effects such as decreasing sexual libido and causing erectile dysfunction. Dapoxetine, on the other hand, is a fast-acting SSRI. It is rapidly absorbed and eliminated from the body within a few hours. This favorable pharmacokinetics minimizes the risk of the drug’s accumulation in the body, and therefore reducing side effects.

 

Dapoxetine COA:

 

Name /
CAS No. 119356-77-3
ITEMS STANDARD RESULTS
Characteristics White or almost white crystalline powder White crystalline powder
Melting point 175.0~177.0°C 174.0~179.0°C
Specific rotatlon +128°±3(C=1,CH3OH) +128°±3(C=1,CH3OH)
Loss on drying ≤0.5% 0.32%
Heavy metals 0ppm 0ppm
Relative substance ≤0.1%
Total impurity
0.07%
Assay(on drled basis) ≥99.5% 99.61%
Conclusion It complies to prescrlbed enterprise standard

 

Dapoxetine Usage and Dosage:

 

Room 20 to 30 minutes before oral administration, each one, may be taken on a fixed day. Fasting (especially to avoid the same clothes with high-fat foods) better, do not drink tea before use. Users have sexual stimulation in the use of the effect was significant.

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