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Dapoxetine Hydrochloride (Dapoxetine HCL) Powder (129938-20-1)

 

Product Name:Dapoxetine
Also known as:Dapoxetine Hcl, Dapoxetine hydrochloride
Appearance:White powder
Standard:USP / EP / IP
Purity:Not Lower Than 99.00%
Application Type:Oral Tablets / Pills
Supplying Form:Pure Raw Powder
Certification:ISO9001:2008 , SGS , Pharmacopoeia Grade
Place of Origin:China

 

Dapoxetine Hydrochloride Description:

 

1. Dapoxetine hydrochloride is an oral drug for the treatment of ED, used in the treatment of erectile dysfunction and premature ejaculation, erectile function impairment and premature ejaculation has very significant improvements。

2. There are over 1500 documents to prove the caused by different causes impotence premature ejaculation, knew the success rate is above 80%, and show its reliable curative effect, through the use of more than 20 million people worldwide, proved its long-term stability, the safety of 25 to 60 minutes of work function to coincide with a time needed for foreplay, knew the time adjustment in the highest drug concentration time, help both husband and wife a satisfactory sex life.

3. Initially, dapoxetine hydrochloride is given as a 30 mg tablet one to three hours before sexual intercourse. The dose may be increased by the prescribing doctor to 60 mg, depending on response and tolerance.

 

Dapoxetine Hydrochloride Application:

 

1. Treat male premature ejaculation and erectile dysfunction.Dapoxetine, marketed as (among and other brands) is the first compound developed specially for the treatment of premature ejaculation (PE) for men at th age of 18–64 years old. Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin’s action at the post synaptic cleft, so as to delay ejaculation.. As a member of selective serotonin reuptake inhibitor (SSRI) family, Dapoxetine was initially created as an antidepressant. However,unlike other SSRIs, Dapoxetine is absorbed and eliminated rapidly in the body. Its fast response makes it suitable for the treatment of PE but not as an antidepressant.

2. Due to the lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as Fluoxetine, Paroxetine, Sertraline, Fluvoxamine, and Citalopram have been used as clinical drugs to treat PE. Waldinger’s meta analysis shows that the use of these conventional antidepressants increases IELT from two to nine times above base line in comparison of three to eight times when Dapoxetine is used. However, these SSRIs must be taken daily in order to achieve meaningful efficacy, and the long half-life increases the risk of the drug accumulation and as a consequence an increased adverse effects such as decreasing sexual libido and causing erectile dysfunction. Dapoxetine, on the other hand, is a fast-acting SSRI. It is rapidly absorbed and eliminated from the body within a few hours.
This favorable pharmacokinetics minimizes the risk of the drug’s accumulation in the body, and therefore reducing side effects.

 

Dapoxetine Hydrochloride COA:

 

ITEMS STANDARD RESULTS
Characteristics White or almost white crystalline powder White crystalline powder
Melting point 175.0~177.0℃ 174.0~179.0℃
Specific rotatlon +128°±3(C=1,CH3OH) +128°±3(C=1,CH3OH)
Loss on drying ≤0.5% 0.32%
Heavy metals 0ppm 0ppm
Relative substance ≤0.1%
Total impurity
0.07%
Assay(on drled basis) ≥99.5% 99.61%
Conclusion It complies to prescrlbed enterprise standard

 

Dapoxetine Hydrochloride Dosage:

 

Initially, dapoxetine hydrochloride is given as a 30 mg tablet one to three hours before sexual intercourse. The dose may be increased by the prescribing doctor to 60 mg, depending on response and tolerance.

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