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Local Anesthesia Powders

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Mepivacaine Hydrochloride (Mepivacaine HCL) Powder CAS 1722-62-9

 

Mepivacaine hydrochloride
CAS: 1722-62-9
MF: C15H22N2O.ClH
MW: 282.81
EINECS: 217-023-9
Synonyms: (1-methyl-dl-piperidine-2-carboxylicacid)-2,6-dimethylanilidehydrochloride;1-methyl-2′,6′-pipecoloxylididehydrochloride;6′-pipecoloxylidide,1-methyl-2monohydrochloride;carbocainehydrochloride;dl-1-methyl-2′,6′-pipecoloxylididehydrochloride;dl-mepivacainehydrochloride;n-(2,6-dimethylphenyl)-1-methyl-2-piperidinecarboxamidmonohydrochloride;1-methyl-2′,6′-pipecoloxylidine hydrochloride
Molecular Weight:282.81
Boiling Point:383.1 C at 760 mmHg
Melting Point:255-257C (dec.)
Flash Point:185.5 C
standard:Enterprise standard
Assay:99%
Appearance:White or off white crystalline powder
Application:An anti-inflammatory and analgesic

 

Mepivacaine Hydrochloride Description:

 

Mepivacaine is a local anesthetic of the amide type. Mepivacaine has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine) and is marketed under various trade names including Carbocaine and Polocaine.
Mepivacaine is used in any infiltration and regional anesthesia.
It is supplied as the hydrochloride salt of the racemate.

 

Mepivacaine Hydrochloride Applications:

 

Mepivacaine hydrochloride to stabilize the neuronal membrane, to prevent the occurrence and spread of nerve impulses, and thus local anesthesia.

The rapid metabolism of mepivacaine hydrochloride, only a small part of the anesthetic (5% to 10%) excretion in the urine unchanged. Methapine is not detoxified by circulating plasma esterase because of its amide structure. The liver is the main site of metabolism, more than 50% of the dose as a metabolite is excreted into the bile. Most metabolized mepivacaine may be absorbed in the intestine and then excreted into the urine because only a small fraction is found in the feces.

The main way to excrete is through the kidneys. Most anesthetics and their metabolites are eliminated within 30 hours. It has been shown that hydroxylation and N-demethylation as detoxification play an important role in the metabolism of anesthetics. Three metabolites of mepivacaine have been identified from adults: two phenols are almost completely excreted as glucuronide conjugates, and N-demethylated compounds.

 

Mepivacaine Hydrochloride COA:

 

Product name Mepivacaine HCl
Appearance White crystalline powder
Assay (C13H20N2O2·HCl) 99.0% to 101.0% 99.50%
Melting point 153~158ºC 156.5~157.0ºC
Heavy metals ≤20ppm <5ppm
Acidity ≤0.02N NaOH 0.5ml 0.3ml
Chromatographic purity Secondary spots≤0.5%,sum≤1.0% Conforms
Loss on drying ≤1.0% 0.06%
Residue on ignition ≤0.15% 0.03%
Bacterial endotoxins ≤0.6EU/mg <0.6EU/mg
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